No. 2 seed Xavier lost to No. 7 seed Wisconsin, 66-63, on a buzzer-beater in their second-round NCAA Tournament showdown in St. Louis.
The Muskies led the Badgers, 33-30, at the half.
Up next is Notre Dame, a 76-75 winner Sunday against Cinderella Stephen F. Austin, in the Sweet 16 in Philadelphia.
The Musketeers are playing in their sixth Big Dance in seven years and own the highest seed in program history.
Xavier (28-5) and Wisconsin (21-12) hadn’t met since 2009, an NCAA Tournament second-round game the Musketeers won 60-49.